 | Dennis Quaid | as | Charlie Wessler (segment "The Pitch") |
 | Greg Kinnear | as | Griffin Schraeder (segment "The Pitch") |
 | Common | as | Bob Mone (segment "The Pitch") |
 | Charlie Saxton | as | Jay (segment "The Pitch") |
 | Will Sasso | as | Jerry (segment "The Pitch") |
 | Odessa Rae | as | Danita (segment "The Pitch") |
 | Seth MacFarlane | as | Seth MacFarlane (segment |
| Mike Meldman | as | Mike Meldman (segment "The Pitch") |
 | Hugh Jackman | as | Davis (segment "The Catch") |
 | Kate Winslet | as | Beth (segment "The Catch") |
 | Julie Claire | as | Pamela (segment "The Catch") |
 | Katie Finneran | as | Angie (segment "The Catch") |
| Roy Jenkins | as | Ray (segment "The Catch") |
| Rocky Madigan | as | Waiter Jake (segment "The Catch") |
| Anna Madigan | as | Abby (segment "The Catch") |
 | Jeremy Allen White | as | Kevin (segment "Homeschooled") |
 | Liev Schreiber | as | Robert (segment "Homeschooled") |
 | Naomi Watts | as | Samantha (segment "Homeschooled") |
| Alex Cranmer | as | Sean (segment "Homeschooled") |
| Austin Cope | as | High School Student (segment "Homeschooled") |
 | Julie Ann Emery | as | Clare (segment "Homeschooled") |
 | Anna Faris | as | Vanessa (segment "The Proposition") |
 | Chris Pratt | as | Jason (segment "The Proposition") |
 | J. B. Smoove | as | Larry (segment "The Proposition") |
| Jarrad Paul | as | Bill (segment "The Proposition") |
| Maria Arcé | as | Christine (segment "The Proposition") |
| Aaron LaPlante | as | Friend (segment "The Proposition") |
 | Kieran Culkin | as | Neil (segment "Veronica") |
 | Emma Stone | as | Veronica (segment "Veronica") |
| Arthur French | as | Old Man (segment "Veronica") |
| Brooke Davis | as | Tall Lady (segment "Veronica") |
| John Shuman | as | Short Guy (segment "Veronica") |
| Cathy Cliften | as | Robert (segment "iBabe") |
| Cherina Monteniques Scott | as | iBabe #2 (segment "iBabe") |
 | Richard Gere | as | Robert (segment "iBabe") |
 | Kate Bosworth | as | Arlene (segment "iBabe") |
 | Jack McBrayer | as | Brian (segment "iBabe") |
 | Aasif Mandvi | as | Robert (segment "iBabe") |
| Zach Lasry | as | Boy (segment "iBabe") |
| Darby Lynn Totten | as | Woman (segment "iBabe") |
| Marc Ambrose | as | Chappy (segment "iBabe") |
 | Justin Long | as | Fake Wonder Woman (segment "Super Hero Speed Dating") |
 | Jason Sudeikis | as | Fake Batman (segment "Super Hero Speed Dating") |
 | Uma Thurman | as | Fake Lois Lane (segment "Super Hero Speed Dating") |
 | Bobby Cannavale | as | Fake Superman (segment "Super Hero Speed Dating") |
 | Kristen Bell | as | Fake Supergirl (segment "Super Hero Speed Dating") |
 | John Hodgman | as | Fake Penguin (segment "Super Hero Speed Dating") |
 | Leslie Bibb | as | Fake Wonder Woman (segment "Super Hero Speed Dating") |
| Will Carlough | as | Fake Riddler (segment "Super Hero Speed Dating") |
 | Katrina Bowden | as | Woman (segment "Super Hero Speed Dating") |
| Phil Crowley | as | Narrator (segment "Machine Kids") |
| Ed Blythe | as | Vending Machine Man (segment "Machine Kids") |
| Olivia Roberts Payne | as | Vending Machine Child (segment "Machine Kids") |
| Monique Delee | as | Vending Machine Child (segment "Machine Kids") |
| Jaron Henrie-McCrea | as | ATM Man (segment "Machine Kids") |
| Sebastian Brodziak | as | ATM Child (segment "Machine Kids") |
| Severyn K. Brodziak | as | ATM Child (segment "Machine Kids") |
| Rightor Doyle | as | Photocopier Man 1 (segment "Machine Kids") |
| Raven Burnett | as | Photocopier Man 2 (segment "Machine Kids") |
| Montana Byrne | as | Photocopier Child (segment "Machine Kids") |
| Jarrett Carter | as | Photocopier Child (segment "Machine Kids") |
| Phillip Michaels | as | Photocopier Child (segment "Machine Kids") |
 | Christopher Mintz-Plasse | as | Mikey (segment "Middleschool Date") |
 | Chloë Grace Moretz | as | Amanda (segment "Middleschool Date") |
 | Patrick Warburton | as | Dad (segment "Middleschool Date") |
 | Jimmy Bennett | as | Nathan (segment "Middleschool Date") |
 | Matt Walsh | as | Amanda's Dad (segment "Middleschool Date") |
| Coleen Hoffman | as | Blonde Woman (segment "Tampax") |
| Elbe Van Der Merwe | as | Brunette Woman (segment "Tampax") |
 | Gerard Butler | as | Leprechaun 1 & 2 (segment "Happy Birthday") |
 | Seann William Scott | as | Pete (segment "Happy Birthday") |
 | Johnny Knoxville | as | Pete (segment "Happy Birthday") |
| Esti Ginzburg | as | Fairy (segment "Happy Birthday") |
 | Halle Berry | as | Emily (segment "Truth or Dare") |
 | Stephen Merchant | as | Donald (segment "Truth or Dare") |
 | Sayed Badreya | as | Large Man (segment "Truth or Dare") |
 | Nicole 'Snooki' Polizzi | as | Snooki (segment "Truth or Dare") (as Nicole Elizabeth Polizzi) |
| Caryl Lippman West | as | Waitress (segment "Truth or Dare") |
| Ricki Noel Lander | as | Nurse Elizabeth (segment "Truth or Dare") |
| Paloma Felisberto | as | Bachelorette Party Girl (segment "Truth or Dare") |
| Jasper Grey | as | Patron (segment "Truth or Dare") |
| Ben Harris | as | Blanco the Bartender (segment "Truth or Dare") |
 | Zen Gesner | as | Stripper (segment "Truth or Dare") |
 | Terrence Howard | as | Coach Jackson (segment "Victory's Glory") |
| Aaron Jennings | as | Anthony (segment "Victory's Glory") |
| Jared Dudley | as | Moses (segment "Victory's Glory") |
| Corey Wayne Brewer | as | Wallace (segment "Victory's Glory") |
| Larry Eugene Sanders II | as | Bishop (segment "Victory's Glory") |
| Jay Ellis | as | Lucious (segment "Victory's Glory") |
| Brian Flaccus | as | White Guy 1 (segment "Victory's Glory") |
 | Brett Davern | as | White Guy 2 (segment "Victory's Glory") |
| Evan Dumouchel | as | White Guy 3 (segment "Victory's Glory") |
| Sean Rosales | as | White Guy 4 (segment "Victory's Glory") |
| Logan Holladay | as | White Guy 5 (segment "Victory's Glory") |
| Mandy Kowalski | as | Cheerleader (segment "Victory's Glory") |
 | Eric Stuart | as | Narrator (segment "Victory's Glory") |
 | Elizabeth Banks | as | Amy (segment "Beezel") |
 | Josh Duhamel | as | Anson (segment "Beezel") |
| Emily Alyn Lind | as | Birthday Girl (segment "Beezel") |
| Michelle Gunn | as | Mommy (segment "Beezel") |
| Christina Linhardt | as | Party Clown (segment "Beezel") |
| Adam Cagley | as | JJ (uncredited) |
| Devin Eash | as | Baxter (uncredited) |
 | Mark L. Young | as | Calvin (uncredited) |
 | Julie McNiven | as | ATM Woman (segment "Machine Kids") |